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Inflammatory Disease
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Inflammation of the walls of vessels called vasculitis, is encountered in diverse disease and clinical settings. Vessels of any type in virtually any organ can be affected; this leads to a wide spectrum of clinical manifestations, which often includes constitutional signs and syumptoms , such as fever, myalgias, artralgias, and malaise. The two most common mechanisms of vasculitis are immune-mediated inflammation and direct invasion of vascular walls by infectious pathogens. Infections can directly induce a noninfectious vasculitis , for example by generating immune complexes or triggering cross-reactivity. In a particular patient, it is critical to distinguish between directly infectious and immunologic mechanisms because the treatment approaches differ widely for example the immunosuppressive therapy appropriate for immune mediated vasculitis would be potentially harmful for infectious vasculitis. Physical and chemical injury, such as irradiation , mechanical trauma and toxins, can also cause vascular damage. In such cases one or a relatively few vessels may be affected, as for example in a localized area of infection , irradiation, or mechanical trauma.
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